References

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  2. Bouhss, A., Trunkfield, A. E., Bugg, T. D. & Mengin-Lecreulx, D. (2008) The biosynthesis of peptidoglycan lipid-linked intermediates. FEMS Microbiology Reviews. 32 (2), 208-233.
  3. Bugg, T. & Walsh, C. (1992) Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance. Natural Product Reports. 9 (3), 199-215.
  4. Chung, B. C., Zhao, J., Gillespie, R. A., Kwon, D. Y., Guan, Z., Hong, J., Zhou, P. & Lee, S. Y. (2013) Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis. Science (New York, N.Y.). 341 (6149), 1012-1016.
  5. White, D., Drummond, J. T. & Fuqua, C. (2007) The physiology and biochemistry of prokaryotes. , Oxford University Press New York.
  6. Teo, A. and Roper, D. (2015). Core Steps of Membrane-Bound Peptidoglycan Biosynthesis: Recent Advances, Insight and Opportunities. Antibiotics, 4(4), pp.495-520.
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  8. Lloyd, A. J., Brandish, P. E., Gilbey, A. M. & Bugg, T. D. (2004) Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues. Journal of Bacteriology. 186 (6), 1747-1757.
  9. Roos, C., Zocher, M., Müller, D., Münch, D., Schneider, T., Sahl, H., Scholz, F., Wachtveitl, J., Ma, Y. & Proverbio, D. (2012) Characterization of co-translationally formed nanodisc complexes with small multidrug transporters, proteorhodopsin and with the E. coli MraY translocase. Biochimica Et Biophysica Acta (BBA)-Biomembranes. 1818 (12), 3098-3106.
  10. Mihalyi, A., Jamshidi, S., Slikas, J. & Bugg, T. D. (2014) Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B. Bioorganic & Medicinal Chemistry. 22 (17), 4566-4571.

1 comment:

  1. Sian Stockton6 January 2016 at 10:27

    The writing is all very clear and the diagrams explaining the purification is well done, although may have been better to have included more about the crystals and how they were produced for this membrane protein since the page was structure determination. The discussion of the active site was really detailed and well done. Medical relevance could have been more detailed. The quiz was also a nice thing to have to end it.

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